• Question: How is gene therapy different than making a transgenic organism?

    Asked by rhooper821 to Ben, Dave, Ed, Sam, Susana on 18 Jun 2013.
    • Photo: Benjamin Hall

      Benjamin Hall answered on 18 Jun 2013:


      In short: it isn’t.

      Gene therapy is one of the many applications of the process known as genetic engineering. When gene therapy is used, a gene is integrated into a human’s DNA. That gene is from ‘outside’ of the genome of the organism it’s being inserted into so is known as a ‘transgene’.

      There’s a techincal point that if you introduce the gene to the body cells of the patient, then the gene won’t be stable in the patient so you haven’t really made a transgenic organism. However, if the gene therapy is applied to a sperm or egg cell, or a very early embryo, then you are creating a transgenic organism.

    • Photo: David Briggs

      David Briggs answered on 18 Jun 2013:


      I would say they are similar but not the same.

      Gene therapy is injecting a gene into an organism to make it make more of the gene product – so only the cells around the injection site are altered.

      A transgenic organism is one that is genetically altered before birth, so every cell has the altered copy of the gene.

Comments